Cocaine exposure during the brain growth spurt failed to produce cerebellar Purkinje cell loss in rat pups

Teratology ◽  
1996 ◽  
Vol 53 (3) ◽  
pp. 145-151 ◽  
Author(s):  
Wei-Jung A. Chen ◽  
Robert E. McAlhany ◽  
Susan E. Maier ◽  
James R. West
Keyword(s):  
Purkinje Cell ◽  
Cell Loss ◽  
Cerebellar Purkinje Cell ◽  
Growth Spurt ◽  
Brain Growth ◽  
Cocaine Exposure ◽  
Rat Pups ◽  
Brain Growth Spurt ◽  
Purkinje Cell Loss ◽  
The Brain

scholarly journals The effect of early postnatal undernutrition on the growth and development of the rat brain

1982 ◽  
Vol 48 (1) ◽  
pp. 15-23 ◽  
Author(s):  
B. L. G. Morgan ◽  
D. J. Naismith
Keyword(s):  
Post Partum ◽  
Growth Spurt ◽  
Brain Growth ◽  
Peak Activity ◽  
Cellular Processes ◽  
The Third ◽  
Rat Pups ◽  
Low Protein ◽  
Brain Growth Spurt ◽  
The Brain

1. Rat pups were undernourished during the period of the brain growth-spurt by feeding their mothers a low-protein diet from the third day post partum.2. The pups were killed on days 5,6,9,12,16,20 and 24 post partum, and their brains were analysed for protein, DNA, glycosides and glycoproteins. The activities of four enzymes involved in neurotransmission, and in the synthesis of glycolipids and myelin were also measured. Results of the analyses were compared with those obtained for pups that were suckled by well-nourished dams.3. The brains of the undernourished pups contained substantially less protein and DNA; gangliosides and glycoproteins were also reduced.4. All four enzymes showed lower peak activities in the nutritionally deprived animals, and the attainment of peak activity was retarded by several days.5. These results suggest that undernutrition imposed during the brain growth-spurt leads to a deficit in the glial cell population and thus in the capacity to form myelin, and reduced deveiopment of cellular processes.

Reduced Seizure Threshold and Hippocampal Cell Loss in Rats Exposed to Alcohol During the Brain Growth Spurt

2001 ◽  
Vol 25 (1) ◽  
pp. 70-82 ◽  
Author(s):  
Daniel J. Bonthius ◽  
Justin Woodhouse ◽  
Nancy E. Bonthius ◽  
Derek A. Taggard ◽  
Eric W. Lothman
Keyword(s):  
Cell Loss ◽  
Seizure Threshold ◽  
Growth Spurt ◽  
Brain Growth ◽  
Hippocampal Cell ◽  
Brain Growth Spurt ◽  
The Brain

GABAA overactivation potentiates the effects of NMDA blockade during the brain growth spurt in eliciting locomotor hyperactivity in juvenile mice

2015 ◽  
Vol 50 ◽  
pp. 43-52 ◽  
Author(s):  
Juliana Oliveira-Pinto ◽  
Danielle Paes-Branco ◽  
Fabiana Cristina-Rodrigues ◽  
Thomas E. Krahe ◽  
Alex C. Manhães ◽  
...  
Keyword(s):  
Growth Spurt ◽  
Brain Growth ◽  
Locomotor Hyperactivity ◽  
Brain Growth Spurt ◽  
The Brain
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